Volume: Purified: 100 µL; Purified Trial: 20 µL; TC Supernatant: 5 mL

Concentration: Purified: 1 mg/mL; TC Supernatant: Lot Specific

Clonality: Monoclonal

Form: Purified and TC Supernatant Available (select your preferred form, size and quantity before clicking "Add to Cart")

Host Species: Mouse

Immunogen: Fusion protein amino acids 1-544 (full-length) of rat RGS14 (also known as Regulator of G-protein signaling 14, RAP1/RAP2-interacting protein and RPIP1, accession number O08773)Mouse: 95% identity (524/547 amino acids identical)Human: 86% identity (475/547 amino acids identical)45% identity with RGS12 and other RGS proteinsEpitope mapped to within amino acids 444-490 (between 2nd Ras-binding GoLoco domains, PDAKTREASSIPPCRSQGCLPRTQTKDSHLPPLSSSLSVEDASGSTG, 2014 Evans et al J Comp Neurol)Mouse: 85% identity (40/47 amino acids identical)Human: 51% identity (24/47 amino acids identical)

Target Description: RGS14 is a member of the RGS family (regulator of G-protein signaling) and is highly expressed in the prefrontal cortex. Hallmark domains of RGS14 include a RGS domain, two Raf-like Ras-binding domains and a GoLoco motif. RGS14 inactivates G protein α subunits. Alterations in this protein have been implicated in Schizophrenia and Alzheimer’s disease.

Gene ID: Rgs14

Antibody Registry ID (RRID): AB_2179931

Physical State: Liquid

Validation and Application Notes

Molecular Weight: 60 kDa

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.

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