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主营:抗体、抗鸡、免疫沉淀、神经细胞标记、二抗、阻断试剂
℡ 4000-520-616
℡ 4000-520-616
Aves Labs/Anti-Metabotropic Glutamate Receptor Type 5 (mGluR5) Antibody (ER5)/ER5
产品编号:ER5
市  场 价:¥8200.00
场      地:美国(厂家直采)
产品分类: 抗体类>二抗>抗鸡>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$410.00
品      牌: Aves Labs
公      司:Aves Labs, Inc.
公司分类:
Aves Labs/Anti-Metabotropic Glutamate Receptor Type 5 (mGluR5) Antibody (ER5)/ER5
商品介绍

We have three different anti-mGluR antibodies, each of which binds to a specific peptide sequence(s) present in different sets of mGluR gene family members. The ER5 antibody represents sequences found only in mGluR5. It comprises two antipeptide antibodies generated against two different regions of the mGluR5 gene product not found in other mGluR gene family members. This antibody has been validated for immunohistochemistry and immunocytochemistry using mouse brain sections and cultured neuroblastoma cells as well as in rat brain sections.

Volume: 1000 µL

Concentration: 300 µg/mL

Clonality: Polyclonal

Host Species: Chicken

Species Reactivity:Human, Mouse, Rat

Applications: ICC, IHC

Protein Name / Synonyms: Metabotropic glutamate receptor 5 (mGluR5)

Target Description: The metabotropic glutamate receptors (mGluRs) represent a gene family of G-protein-coupled receptors, all of which bind the amino acid glutamate (the major excitatory neurotransmitter of the nervous system) but differ in their primary amino acid structure, their pharmacology, and their distribution in the peripheral and central nervous systems. In general, mGluR1 and mGluR5 receptors are post-synaptic and mGluR2 and mGluR3 receptors are pre-synaptic.

Gene ID: GRM5 GPRC1E MGLUR5

Antibody Registry ID (RRID): AB_2313544

Physical State: Liquid

Production Notes: Chickens were immunized with three synthetic peptide / keyhole limpet hemocyanin (KLH) conjugates. These synthetic peptides corresponded to different regions of the metabotropic glutamate receptor type 5 gene product, but are shared between the human (NP_001137303.1, NCBI) and mouse (Q3UVX5.2, NCBI) sequences. After repeated injections, immune eggs were collected, and the IgY fractions were purified from the yolks. These IgY fractions were then affinity-purified using a peptide column, and the concentrations of the eluates adjusted to 300 µg/mL. Finally, equal volumes of these affinity-purified anti-peptide antibodies were mixed, and the preparation was filter-sterilized.

Validation and Application Notes

IHC Dilution Range: 1:1000-1:2000

Quality Control

This anti-peptide antibody mixture was analyzed by immunohistochemistry (at a dilution of 1:2000) using fluorescein-labeled goat anti-chicken IgY (1:500 dilution, Aves Labs Cat.# F-1005) as the secondary reagent.

Storage

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least 12 months (provided they remain sterile). Do not freeze these antibodies unless you want to store them for longer periods of time. Note, however, that each time an antibody preparation is frozen, about half of its binding activity is lost.

NOTE

Aves Labs products are intended for use as research laboratory reagents. They are not intended for use as diagnostic or therapeutic reagents in humans.

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品牌介绍
Aves Labs是一家成立于上世纪九十年代,专注于高亲和性鸡源抗体的研发和准备,生物医药和生命科学行业全球*的鸡多克隆抗体(IgY)及定制抗体/多肽/免疫试剂的专业公司。Aves Labs在鸡源神经系统标志蛋白/抗体研究领域拥有独特优势,不仅品种多样,质量优良,而且适用于人/大小鼠等多个物种的神经系统研究,包括神经元/胶质细胞/雪旺细胞的各亚细胞结构免疫双标/免疫共沉淀研究。公司独有的技术及优质抗体产品有助于全球科研人员更为便捷的解决学术研究及应用研发课题。除了丰富的产品线外,Aves Labs还为客户提供优质的抗体定制服务,您只需要提供需要研究的重组蛋白或合成多肽,我们即可为您生产优质的鸡源多克隆抗体。
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